Setmelano 10mg
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Setmelano 10mg

Original price was: 500.00$.Current price is: 400.00$.

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Setmelanotide: An innovative treatment for genetic obesity

Setmelanotide is a revolutionary therapy for people with deficiencies in POMC, PCSK1 and LEPR, rare genetic diseases causing uncontrollable hunger and severe obesity. By restoring the function of the MC4R pathway, this treatment helps regulate satiety and promotes significant weight loss. Find out how this medical breakthrough can transform patients’ lives.

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Description

Setmelatodide: Understanding POMC, PCSK1 and LEPR deficiencies

What are POMC, PCSK1 and LEPR deficiencies?

POMC, PCSK1 and LEPR deficiencies are rare genetic diseases responsible for a severe form of obesity. They result from a genetic mutation inherited from both parents, disrupting the brain’s control of hunger.

Symptoms and impact on the body

POMC(proopiomelanocortin) deficiency

  • Brain: Insatiable hunger(hyperphagia) and obesity
  • Endocrine: adrenal insufficiency, hypothyroidism, hypoglycemia, growth hormone deficiency
  • Reproductive: delayed puberty(hypogonadotropic hypogonadism)
  • Other: Fair skin, red hair, hepatic insufficiency

PCSK1(pro protein convertase subtilisin/kexin type 1) deficiency

  • Brain: Insatiable hunger(hyperphagia) and obesity
  • Digestive: gastrointestinal disorders (diarrhea from birth)
  • Kidneys: Acid build-up, excessive thirst
  • Endocrine: diabetes, hypoglycemia, cortisol deficiency
  • Other: Infantile growth retardation

LEPR(leptin receptor) deficiency

  • Brain: Hyperphagia and obesity
  • Endocrine: high insulin levels
  • Reproductive: Delayed puberty
  • Other: Diabetes

Understanding hyperphagia

The hyperphagia associated with these deficits is uncontrollable and different from the usual overeating. It is characterized by :

  • Constant hunger, even after a meal
  • An obsession with food
  • Compulsive foraging behaviour

Treatment: How does Setmelatodide work?

Setmelatodide is a treatment designed to restore the function of the MC4R pathway, which regulates the sensation of satiety.

Clinical effectiveness

Studies have shown significant weight loss and reduced hunger in treated patients:

  • POMC/PCSK1: 80% of patients lost at least 10% of their weight in one year
  • LEPR: 45% of patients lost at least 10% of their weight in one year

Method of administration

  • Daily subcutaneous injection
  • To be taken in the morning, with or without food

Possible side effects

The most common side effects include:

  • Injection site reactions (96%)
  • Darkening of the skin (78%)
  • Nausea, headaches, fatigue, gastrointestinal disorders

Conclusion

Setmelatodide represents a major advance in the management of POMC, PCSK1 and LEPR deficiencies. If you or someone you know is affected, talk to your doctor to find out more about this treatment option.

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